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KMID : 1007520160250010275
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Food Science and Biotechnology
2016 Volume.25 No. 1 p.275 ~ p.281
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Physiological Concentrations of Trans-11 18:1 Vaccenic Acid Suppress Pro-inflammatory Markers under Acute Inflammation in Isolated ICR Mice Splenocytes
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Lee Jae-Sung
Lim Ji-Na
Wang Tao
Lee Sang-Bum
Hwang Jin-Hee
Jung U-Suk
Kim Min-Jeong
Choi Seong-Ho
Satoshi Ishizuka
Lee Hong-Gu
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Abstract
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Direct influences of dietary trans-11 18:1 vaccenic acid (TVA) at physiological concentrations of 50-200 μM were evaluated for cell growth, cytotoxic activity, and cytokine production in leukocytes isolated from the mouse spleen. TVA supplementation for 24 h induced growth of splenocytes at concentrations of 50-200 μM, except for 100 μM. The cytokines TNFα, IFNγ, and IL-10 of splenocytes were stimulated by 100 μM TVA. Induced production of TNFα in splenocytes challenged with lipopolisaccharides was suppressed by 100 μM TVA. Physiological levels of TVA had direct effects on growth and cytokine production in splenocytes. Further in vivo studies are needed to improve understanding of the precise influence of trans fatty acids on production of pro-inflammatory markers under acute inflammation conditions.
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KEYWORD
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cis-9, trans-11-conjugated linoleic acid, trans-11 18:1 vaccenic acid, cytokine production, cell growth, splenocyte
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